Hif-1α是什么

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August undefined, 2024

Web26 de abr. de 2013 · Overexpression of HIF-1α showed a time delay in HIF-1β induction, thus arguing for HIF-1β de novo synthesis rather than protein stabilization by heterodimerization. A Hen's egg test-chorioallantoic membrane model of angiogenesis … Web28 de jul. de 2024 · Overexpression of HIF-1α can lead to increased expression of some genes, facilitating cellular resistance against apoptosis caused by hypoxia or lack of nutrients (Akakura et al., 2001; Yang S. et al., 2024). For example, HIF-1α subunits are involved in regulating the activities of many members of the Bcl-2 family (Fang et al., 2024).

SciELO - Brasil - Role of HIF-1α signaling pathway in osteoarthritis ...

Web1 de fev. de 2015 · Hypoxia and inflammation are intimately linked. It is known that nuclear factor κB (NF-κB) regulates the hypoxia-inducible factor (HIF) system, but little is known about how HIF regulates NF-κB. Here, we show that HIF-1α represses NF-κB-dependent gene expression. HIF-1α depletion results in increased NF-κB transcriptional activity both … Web10 de out. de 2024 · 细胞信号通路详解之HIF1α通路. 2024-10-10 22:30. 动物细胞中，对氧气的感知和反应是一个非常重要的过程，在包括癌症、心血管疾病和中风在内的多种疾病的病理生理学中占有重要地位。. 该过程主要由HIF（缺氧诱导因子）及其调节子pVHL … greenfield renewable energy co. ltd

Frontiers Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and ...

WebThe oxygen-regulated subunit, HIF-1alpha, is stabilized in cells exposed to hypoxia. The regulation of hypoxic responses by nitric oxide (NO) is believed to have wide pathophysiological relevance, thus we investigated whether NO affects HIF-1 activation … http://html.rhhz.net/SWJSTB/html/2016-8-8.htm WebHIF-1α is a transcriptional factor encoded by the HIF1A gene located within chromosome 14q21-24 and is formed by 15 exons; HIF-1α consists of 826 amino acids and it has a molecular weight of 120 kDa. 48 48 Loboda A, Jozkowicz A, Dulak J. HIF-1 and HIF-2 transcription factors–similar but not identical. fluorocarbon vs mono ice fishing

HIF-1α restricts NF-κB-dependent gene expression to control …

HIF1a siRNA (r), shRNA and Lentiviral Particle Gene Silencers

WebThe present study explores the responses of the hypoxia-inducible factor-1α (HIF-1α) to cold, freezing and anoxia exposures in the freeze tolerant goldenrod gall fly larva, Eurosta solidaginis. Reverse transcription-PCR was used to quantify hif-1α transcript levels; transcripts were significantly elevated by ∼70% in chilled (3 ∘ C ... Web21 de jun. de 2024 · Of note, no difference in the growth of HIF-1α (Del)-tumors and HIF-1α (FL)-tumors was observed in immunocompromised NOD scid gamma (NSG) mice lacking mature B, T, and NK cells (Fig. 2E ... fluorochem moneycontrolWeb30 de jul. de 2024 · Molecular mechanism of hypoxia-inducible factor 1 (HIF-1) signaling. Under normoxia, HIF-1α is hydroxylated by prolyl-4-hydroxylase (PHD) and factor inhibiting HIF-1 (FIH), and interacts with von ... fluorocarbon resin coating

"Web25 de mar. de 2024 · HIF-1α, an essential transcription factor under hypoxic condition, is indispensable for chondrocytes during skeletal development but its expression and roles in articular chondrocytes are yet to ... " - Hif-1α是什么

Hif-1α是什么

Web3 de abr. de 2024 · This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy … WebAs a test of HIF-1α function, the ability of hypoxia to increase HIF-1α-dependent transcription was measured using a reporter construct containing a promoter with a HIF-1α-responsive element. Cells grown in the presence of IL-3 displayed a sixfold increase in HIF-dependent transcriptional activity when cultured under hypoxic conditions ( Fig. 2E ).

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WebHIF 抗体可用于分析细胞对 HIF si/shRNA基因沉默的应答 ChemCruz™ Chemical HIF Inhibitors or HIF Activators 可用于HIF细胞反应的功能性分析 Web15 de fev. de 2001 · Because HIF-1 is regulated by reactive oxygen species, investigation of the impact of reactive nitrogen species was intended. By using different nitric oxide (NO) donors, dose- and time-dependent HIF-1α accumulation in close correlation with the release of NO from chemically distinct NO donors was established.

Web1 de fev. de 2004 · Hence, the blocking of HIF-1a itself or HIF-1α interacting proteins inhibit tumor growth. Based on these findings, HIF-1 can be a prime target for anticancer therapies. Web29 de fev. de 2004 · Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a constitutively expressed HIF-1beta subunit and one of …

Web8 de ago. de 2016 · 缺氧诱导因子-1α（hypoxia inducible factor-1α，HIF-1α）是缺氧条件下广泛存在于哺乳动物和人体内的一种转录因子，是应答缺氧应激的关键因子。HIF-1α是缺氧诱导因子-1（hypoxia inducible factor-1，HIF-1）的一个亚单位，受缺氧调控并调节HIF … Web14 de abr. de 2024 · 4、hif-1α的细胞聚集与表达水平变化. 从图5可以看出，3 组样品hif-1α在0.5 h时聚集程度（图中红色标记）不明显，但随着宰后成熟时间的延长，hif-1α聚集程度不断升高。h2o2处理组hif-1α聚集程度明显高于对照组和nac处理组。如图6所示，宰后成熟0.5～24 h内h2o2处理组 ...

Webhif-1α的中文意思：《英汉医学词典》HIF-1α …，查阅hif-1α的详细中文翻译、例句、发音和用法等。

Web15 de set. de 2024 · Hypoxia‑inducible factor‑1α (HIF‑1α) is essential for regulating the osteogenic differentiation of periodontal ligament cells (PDLCs). The regulatory mechanism of HIF‑1α transcription is still not clear. Recently, two long non‑coding RNAs, HIF1A antisense RNA 1 (HIF1A‑AS1) and HIF1A antisense RNA 2 (HIF1A‑AS2), were found to … greenfield reserve baraboo wiWebDespite its name, HIF-1 is induced not only in response to reduced oxygen availability but also by other stimulants, such as nitric oxide, or various growth factors. HIF-1 and Its Signaling Pathways In a hypoxic … fluorochinolony interakcjeWebHypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong correlation between elevated levels of HIF-1 and tumor metastasis, angiogenesis, poor patient prognosis as … fluorochemical productsWeb21 de mar. de 2024 · GeneCards Summary for HIF1A Gene. HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Retinal Ischemia and Enchondromatosis, Multiple, Ollier Type . Among its related … fluorocarbon water repellentHypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. The Nobel Prize in Physiology or Medicine 2024 was awarded for the discovery of HIF. HIF1A is a basic helix-loop-helix PAS domain containing protein, and is consider… fluorochloromethaneWeb27 de jan. de 2024 · Objective: To summarize the structure, regulatory mechanism, and target genes of hypoxia-inducible factor-1 alpha (HIF-1α) and to comprehensively expound its role in various chronic liver diseases, thus providing a new perspective on the treatment of various liver diseases. Background: Liver disease, especially chronic liver disease, is a … greenfield research ohioWeb11 de abr. de 2000 · Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates cellular and systemic homeostatic responses to reduced O 2 availability in mammals, including angiogenesis, erythropoiesis, and glycolysis. HIF-1 activity is controlled by the O 2-regulated expression of the HIF-1α subunit.Under nonhypoxic conditions, HIF-1α protein … fluorocarbon vs braided fishing line