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WebMay 19, 2024 · The gametocyte development protein 1 (GDV1) has been described as a key facilitator to trigger sexual commitment. GDV1 interacts with the silencing factor … WebMay 19, 2024 · GDV1 interacts with the silencing factor heterochromatin protein 1 (HP1), leading to its dissociation from heterochromatic DNA at the genomic locus encoding AP2-G, the master transcription factor ... main characters in a good man is hard to find
GDV1 induces sexual commitment of malaria parasites by
WebOct 30, 2024 · Using a GDV1 overexpression line we show that the truncation in the GDV1 C-terminus does neither interfere with the nuclear import of GDV1 nor its interaction with HP1 in vitro , but appears important to sustain GDV1 protein levels and thereby sexual commitment. Importance Transmission of malaria causing Plasmodium species by … WebThe DD1-WH Kitis designed for use on water heater applications. It is designed to detect water leaks and shut-off waterlines and sound an audible alarm upon detection of water … WebHere, we identify gametocyte development 1 (GDV1) as the first upstream activator of the sexual differentiation pathway in P. falciparum. Induction of GDV1 expression is sufficient to activate AP2-G expression and sexual differentiation. We found that GDV1 targets heterochromatin and triggers HP1 eviction preferentially at ap2-g and other ... main characters in a book