WebAug 15, 2024 · We propose a positive role for CRBN in NK cells, demonstrating that it is required for initial signaling events triggered by NK cell binding to target cells. Indeed, … WebThe reliability score is divided into Enhanced, Supported, Approved, or Uncertain, and is displayed on both Tissue Atlas and Pathology Atlas. Antibodies used for this assay. …
Epigenetic regulation of - PNAS
WebSep 18, 2024 · Cereblon (CRBN) as a multifunctional protein has been extensively studied. Here, we show that CRBN is a negative regulator of bactericidal activity and autophagy activation. Mitochondrial localization of CRBN was significantly increased in response to Toll-like receptor 4 (TLR4) stimulation. WebChimeric antigen receptor (CAR) T cell therapy has emerged as a new opportunity for cancer treatment; however, resistance can occur due to intrinsic (T cells), extrinsic (tumors), or acquired (tumors) factors. In many cases, the knowledge of these mechanisms comes from clinical observations of patients treated with CAR T cells. In addition, the structure … flight aa5367
Depletion of the - ScienceDirect
WebFeb 11, 2024 · Although we also detected activation of ERK and WNT signaling in some resistant cell lines that have reduced CRBN expression, introduction of exogenous wild … WebWe propose a positive role for CRBN in NK cells, demonstrating that it is required for initial signaling events triggered by NK cell binding to target cells. Indeed, CRBN depletion was associated with a lower ability to form conjugates with target cells and less mature synapses leading to reduced NK cell killing. ... For analysis of CRBN at NK ... WebCereblon (CRBN) is a substrate receptor protein for the CRL4A E3 ubiquitin ligase complex. In this study, we report on a new regulatory role of CRBN in TLR4 signaling. flight aa5488