Chimeric polynucleotide
WebU.S. Patent Application US20160108395A1 for chimeric single-stranded polynucleotides and double-stranded antisense agents useful for modifying the expression of a target gene by means of an antisense effect are disclosed. The chimeric single-stranded antisense polynucleotide and double-stranded antisense agents comprise a central nucleotide … WebPolynucleotide definition, a sequence of nucleotides, as in DNA or RNA, bound into a chain. See more.
Chimeric polynucleotide
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WebThe polynucleotide sequence of the 2A peptide in the chimeric polynucleotide may be modified or codon optimized by the methods described herein and/or are known in the art. Notwithstanding the foregoing, the chimeric polynucleotides of the present invention may comprise a region or part which is not positionally modified or not chimeric as ... WebSep 10, 2024 · In particular, the invention provides chimeric antigen receptors (CARs) comprising such CCR9 binding domains. WO2024037125A1 - Binding domain - Google Patents ... the cell, the polynucleotide, the vector and/or the pharmaceutical composition may be administered to a subject having an existing disease or condition in order to …
WebBR-0112566-A chemical patent summary. WebJul 7, 2016 · We claim: 1. A chimeric polynucleotide encoding a polypeptide, said chimeric polynucleotide having a sequence comprising Formula I, 5′[A n] x-L1-[B o] y-L2-[C p] z-L3 3′ I wherein: each of A and B independently comprise a region of linked nucleosides; C is an optional region of linked nucleosides; at least one of regions A, B, or …
WebDec 4, 2024 · Chimeric nucleases enable genome editing in eukaryotic cell. Targeted genome editing with the hope of treating and curing diseases … WebMar 3, 2024 · Chimeric antigen receptors (CARs) allow T cells to recognize and kill cancer cells independent of antigen presentation in human leukocyte antigens (HLAs). Blockade …
Web3.5 Polynucleotides. A polynucleotide is a combination of nucleotide monomers which are connected to each other through covalent bonds. A single polynucleotide molecule …
WebSep 26, 1995 · A chimera oligonucleotide is provided that can be used in a process for obtaining transcripts and/or amplification of a target sequence of a nucleic acid, ... An oligonucleotide sequence is called "DNA type" if it is comprised of DNA or if it is a modified polynucleotide sequence that, in addition to the nucleic acid strand hybridization ... dgg transport cumbernauldWebFeb 10, 2024 · The method according to claim 1 comprising: (a) providing a first chimeric polynucleotide comprising as operably linked components: (i) a polynucleotide capable of controlling expression in the host cell; and (ii) a polynucleotide encoding a SLAM polypeptide; and (b) providing a second chimeric polynucleotide comprising as … cibc not respondingWebThe chimeric polynucleotide may contain or encode one or more long noncoding RNA (IncRNA, or lincRNA) or portion thereof, a small nucleolar RNA (sno-RNA), micro … cibc northwoodsWebDec 3, 2004 · The term “mutated or chimeric gene” is used to indicate that mutated or chimeric polynucleotides are obtained at a high frequency by using the method … dg grow f3WebDec 12, 2001 · To induce immune responses that might be therapeutic as well as prophylactic for PV infection, we constructed chimeric polynucleotide vaccines incorporating the L1 capsid gene (pH6L1Δ) with segments of E7, an non-structural protein of PV found abundantly in infected cells, added to the C terminus. dgg twitchWebNov 12, 2024 · This invention encompasses RNAi molecules for suppressing DNA encoding GST-π, ribozymes, antisense nucleic acids, DNA/RNA chimeric polynucleotides, and vectors for expressing them, and dominant negative variants of GST-π. cibc offer letterWebThe invention relates to compositions and methods for the preparation, manufacture and therapeutic use of chimeric polynucleotide molecules, which allow for customized … cibc officer